Iohexol

Chemname: N,N'-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodoisophthalamide Molecular Formula: C19H26I3N3O9 transparency of 10% water solution clear transparency of 10% water solution clear color of 10% water solution may Y7 5-acetamido-N,N'-bis(2,3- dihydroxypropyl)-2,4,6- triiodoisophthalamide < 0.5% (other impurity)(HPLC) < 0.1% total impurity)(HPLC < 1.5% 3-chlorine-1,2-propanediol < 100 ppm methanol < 50 ppm 2-methoxy ethanol < 100 ppm propanol < 100 ppm Dissociated amine aromatic < 0.05% Dissociated iodide < 0.002% Hydronium mixture < 0.05% Heavy metals < 0.001% Water < 4.0% Assay 98.0 - 102.0 % 0-alkylate < 0.6% Ethanol < 2000 ppm Ethyl acetate < 50 ppm Microbe test < 100 cfu/g LAL test < 0.2 USP Endotoxin Unit/50 mg I Uses: Iohexol is used as raw material to produce water-soluble nonionic X-CT contrast agent in pharmaceutical factory. The trade name of this contrast agent is called as Iohexol Omnipaque. This contrast agent is often used to inject into vein before CT radiography diagnosis for radiographing blood vessel, urinary system, spinal cord, hip joint and lymphatic system, with many advantages such as low radiography density, low toxicity and good tolerance. At present, it is one of the best contrast agents, has completely substituted for the ionic contrast agents in developed countries.