metronidazole i.v. infusion 100ml:200mg-100ml:200mg
metronidazole i.v. infusion 100ml:200mg Description
Origin: Hebei, China
Minimum Order quantity: 10,000bottles
HS Code: 300490
Name: Metronidazole Injection
Structural formula: C6H9N3O3
Description the product is colorless or almost colorless pellucid liquid.
Pharmacology and toxicity
Potent Anaerobicidal Nitro -imidazole derivative. The exact mechanism of action of metronidazole is unknown. At physiologic pH, metronidazole is un-ionized and taken up readily by anaerobic organisms. The drug then undergoes intracellular chemical reduction via mechanisms unique to anaerobes. Reduced metronidazole interacts with DNA and inhibits nucleic acid synthesis, leading to cell death. Metronidazole is equally effective against dividing and nondividing cells.
Pharmacokinetics
The peak value is observed 20mins after administering by intravenous drip and binding rate with protein <5%. After absorption Metronidazole distributes widely in all kinds of tissues and body liquids, and pass easily blood brain barrier to the tissues such as saliva, placenta, bile, latex, ammiotic fluid, semen, urine, purulence, cerebrospinal fluid and etc. It is reported that the concentration in placenta, latex, bile is similar with that in plasma.
For the healthy people the concentration of Metronidazole in the cerebrospinal fluid is about 43% of that in the plasma, and the effective concentration can remain 12hours. 60～80% of the preparation is excreted via kidney, about 20% of Metronidazole is excreted unchanged in the urine, the other is excreted in the urine as the products of metabolism (25%- glucuronicacid combo, 14%-other kinds of products of metabolism). 10% of Metronidazole is excreted in the dejection, and 14% is excreted from skin.
Disease treated Metronidazole is mainly used in the treatment of anaerobe bacterial infection.
Specifications 100ml：500mg
Storage instructions Light-resistant and store in well-closed containers.
Package Packed in plastic bottle
Validity Two years
Other Information
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| Minimum Order: |
10000 bottle |
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