Homoharringtonine

Product Name: Homoharringtonine

Othere Name: Omacetaxinemepesuccinate [USAN]; Ceflatonin; Myelostat;4-methyl-cephalotaxin2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate;Cephalotaxine,4-methyl(2r)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioa; Cephalotaxine4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate;

NSC 141633; BRN 5687925;CGX-635; Omapro;UNII-6FG8041S5B; 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl(2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate

 CAS No.:  26833-87-4     

Chemical Formula: C29H39NO9

Formula Weight:545.62g/mol 

Assay: 98%

Appearance: Off-whitepowder

Identification method: Mass, NMR

Applicaton: Omacetaxine/ Homoharringtoninefor the determination and identification, pharmacological experiments.

Pharmacological effect: Omacetaxine/ Homoharringtonine cycle non-specific antineoplastic agents. Depolymerize ribosome; inhibit protein synthesis; reduce mitotic index of he tumor; decrease nucleic acid content of tumor tissue; mainly used in clinical acute promyelocytic leukemia; acute monocytic leukemia, acute myeloid leukemia and malignant lyMelting Pointhoma; can also be used for chronic myeloid leukemia, polycythemia vera psychosis.