Dextromethorphan Hydrobromide BP
group namePharmaceutical Intermediate
-
Min Order1 piece
brand nameTSH
-
update timeFri, 04 May 2012 13:58:21 GMT
Packging & Delivery
Min Order1 piece
Briefing
Detailed
Packaging: 25kg/drum or as customers' request
Assay: 99%min
Usage: This product is central suppressants, mainly inhibit the extension of the brain play a role in the cough center. Cold, acute and chronic bronchitis, pharyngitis, bronchial asthma, tuberculosis and other upper respiratory tract infection caused by phlegm cough less
|
TEST |
RESULT |
SPECIFICATION |
|
Description |
White crystalline powder |
Practically white crystals or crystalline powder having a faint odour. |
|
Solubility |
Complies |
Sparingly soluble in water, freely soluble in alcohol and in chloroform and insoluble in ether. |
|
Identification by a. IR |
Complies |
The infrared absorption spectrum of finely ground sample in potassium bromide dispersion compressed into a pellet, exhibits maxima only at the same wave lengths as that of a similar preparation of the corresponding Dextromethorphan HBr WS |
|
b. UV absorption |
1.58% |
Absorbtivity at 278nm of sample (100μg/ml(on anhydrous basis)solution in 0.1N hydrochloric acid) do not differ from a similar preparation of Dextromethorphan Hydrobromide WS by more than 3.0% |
|
c. With silver Nitrate TS |
Complies |
A yellowish wihte precipitate formed when 5 drops of 2N nitric acid and 2ml of silver nitrate TS are added to 5ml of sample solution. |
|
Melting point |
126.5°C with decomposition |
Melts at about 126°C with decomposition. |
|
Specific optical rotation at 25° |
0.30% |
The specific rotation of the sample at 325nm do (on anhydrous basis) not differ from a similar preparation of (C=1,8 in water) Dextromethorphan hydrobromic WS, by more than 1.0% |
|
Ph (1 in 100) |
6.38 |
Between 5.20 and 6.50 |
|
Water by KF |
4.45% w/w |
Between 3.5and 5.5% w/w |
|
Residue on ignition |
0.04% than 0.001% |
Not more than 0.1% w/w |
|
Limit of N,N-dimethylaniline |
Less than 0.001% |
Not more than 0.001% |
|
Limit of phenolic compounds |
Complies |
No blue-green colour develops |
|
Assay (on anhydrous basis) |
99.58% w/w |
Not less than 98.0% and Not less than 102.0% w/w |
