group namePharmaceutical Intermediate
Min Order1 piece
brand nameTSH
update timeFri, 04 May 2012 13:41:59 GMT
Min Order1 piece
Product Name: Lamivudine
CAS NO.: 134678-17-4
HS NO.:2938901000 Packaging Detail: 25kg per fiber drum
Grade Standard: Medicine Grade
Purity: 99.9%min.
Specifications
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Standard: USP 29, 30
Description: White crystalline powder
Assay: 98.0% to 102.0% anhydrous basis
Packing: 25 KGS/Drum
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Lamivudine is nucleoside antiviral drugs, in vitro and experimental infection in animals the hepatitis B virus (HBV) have a strong inhibition. Lamivudine in HBV infection and normal cell metabolism within three phosphate production lamivudine, which is the active form of lamivudine, both of the HBV polymerase inhibitor, this polymerase is the substrate. Lamivudine three phosphate incorporation into viral DNA chain, blocking viral DNA synthesis. Lamivudine three phosphate do not interfere with the normal cell metabolism nucleoside, it mammalian DNA polymerase α and β weak inhibition of DNA content in mammalian cells has almost no effect. Lamivudine on mitochondrial structure and function of DNA content no obvious toxicity. For the majority of patients with hepatitis B serum HBV DNA test results show that lamivudine can rapidly inhibit the replication of HBV and its continuing effect on the entire treatment process. While serum transaminase to normal, long-term use can significantly improve liver necrosis and inflammatory changes to reduce or stop the progress of liver fibrosis
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