Triptorelin CAS: 57773-63-4

Triptorelin,Hormone Peptides Triptorelin , a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2) , is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts . By causing constant stimulation of the pituitary , it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH) . Like other GnRH agonists , triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer , precocious puberty , estrogen-dependent conditions (such as endometriosis or uterine fibroids) , and in assisted reproduction .

 

Triptorelin,It is also used as therapy in cases of gender dysphoria . Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals) . In the United States , it is sold by Watson Pharmaceuticals as Trelstar . In Iran Triptorelin is marketed under the brand name Variopeptyl (Varian Darou Pajooh).

 

Triptorelin is a gonadotropin-releasing hormone agonist used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone and follicle stimulating hormone.

 

Triptorelin, During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels) , known as a flare effect . In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy . In contrast , gonadotropin-releasing hormone antagonists do not cause a surge , but a sudden reduction of testosterone levels.

 

 

Application

 

Triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions, and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl and Diphereline and Gonapeptyl.

 

In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl.In India, Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA". During the treatment of prostate cancer it does cause a surge of testosterone, known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy.

Triptorelin,Growth Hormone Peptides Triptorelin can be used on its own or with other types of treatment . It may be used before or after surgery or radiotherapy . It may also be used to control prostate cancer that has spread to other parts of the body (advanced or metastatic prostate cancer).

Triptorelin,Triptorelin can be given for months or years , depending on your situation . Some men with advanced prostate cancer may have intermittent therapy with triptorelin . This involves having triptorelin treatment for a few months until the cancer is at a very low level (measured by a blood test called a PSA test) . You then have a break from treatment and restart triptorelin when its needed.

 

Usage and Dosage

 

Triptorelin is usually given once every 4, 12, or 24 weeks. Your dose schedule will depend on the strength of triptorelin you are using. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

 

Triptorelin is injected into a muscle. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.

 

Triptorelin is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

 

Do not shake the mixed medicine or it may foam. Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

 

While using triptorelin, you may need frequent blood tests. Each single use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dos