GHRP-2

GHRP-2, like its brother GHRP-6, is a hexapeptide that is a pure growth hormone secretagogue. In addition, GHRP-2 is a synthetic agonist of ghrelin. Unlike GHRP-6, this peptide does not bring on the heavy hunger side effects associated with GHRP-6; however, some users will notice slight increases in hunger. Somewhere in between GHRP-6 and iPamorelin, this hexapeptide has the ability to be a serious contender when considering which GHRP to use with your GHRH.

 

Remember way back when I addressed the amazing ability GHRP-6 has in improving the production of the hormone ghrelin in the stomach (a hormone that controls hunger and GH release)? Well let me tell you about GHRP-2 and why this peptide is one step better than its little brother GHRP-6. Unlike GHRP-6 , GHRP-2 does not come with the heavy hunger side effect, but still maintains all the benefits of activating ghrelin.

 

3. GHRP-2 effect

 

The single polypeptide chain composed of six amino acids is a growth hormone releasing peptide. This hexapeptide not only functions to stimulate ghrelin release, but it also works to correct production of low level growth hormone. Simply put, GHRP-2 is perfectly designed with the intention of releasing human growth hormone from the pituitary gland. These mechanisms have been shown to promote lean body gains in lean body individuals. Since GHRP-2 is a ghrelin agonist, it helps to promote the secretion of human growth hormone in a two fold process. For one, it acts to boost growth hormone through amplification of the transduction pathway. In addition, it suppresses the action of somatostatin (a hormone which limits the release of growth hormone). These actions make GHRP-2 a perfect option to increase endogenous growth hormone levels.

 

4. How to use GHRP-2 ?

 

In humans, a dose of 1mcg/kg (100mg for a 100kg male) of GHRP-2 when combined with a GHRH of equal dosage creates a three-hour pulse of GH that is double the amplitude of an 8 IU synthetic (e.coli derived) growth hormone dose. IV, intramuscular and subcutaneous routes lead to different onset times but roughly similar peaks and declines.

 

5. The difference between ghrp-2 and ghrp-6

 

While both of these amino acid peptides release growth hormone, there's a noticeable difference in GHRP-6, which speeds up digestion allowing for larger

consumption of food. It's worth adding that this particular peptide is a first-generation GHRP.

What distinguishes GHRP-2 is its ability to cause growth hormone to be released more intensely. This second-generation GHRP is best for those who

want to get the absolute most value from the growth hormone releases. On the other hand, if increasing low appetite is the main concern GHRP-6 would be best.

 

6. GHRP-2 dose and use

 

Like the other peptides we have covered so far, GHRP-2 acts as a lyophilized powder. It must be stored in a cool dry place, should be used for injection of antibacterial water or sodium chloride to rebuild. Once the peptide is reconstituted, GHRP-2 must be stored in a cold storage such as a refrigerator until ready for use. GHRP-2 can take high doses if needed; however, it is unclear how effective these high doses are. Typically, GHRP-2 is used 2-3 times per day, about 100 mcg to 300 mcg per injection. As with other GHRP’s, GHRH can also be used to maximize the effectiveness of the pulse wave combination in obtaining the pituitary pathway for release of growth hormone.