Nadroparin calcium-injectable

Standard: EP
stable supply, credible and high quality.
DMF available

Nadroparin Calcium is the calcium salt oflow-molecular-mass heparin obtained by nitrous acid depolymerisation of heparinfrom pork intestinal mucosa, followed by fractionation to eliminate selectivelymost of the chains with a molecular mass lower than 2000. The majority of thecomponents have a 2-O-sulpho-a-L-idopyranosuronic acid structure at thenon-reducing end and a 6-O-sulpho-2,5-anhydro-D-mannitol structure at thereducing end of their chain.

The mass-average molecular mass ranges between3600 and 5000 with a characteristic value of about 4300.

The degree of sulphatation is about 2 perdisaccharide unit.

The potency is not less than 95 IU and notmore than 130 IU of anti-factor Xa activity per milligram, calculated withreference to the dried substance. The ratio of anti-factor Xa activity toanti-factor IIa activity is between 2.5 and 4.0.