group namePolypeptides
Min Order1 milligram
brand nameJNJG
payment method
update timeWed, 15 Mar 2017 15:24:59 GMT
CAS NO N/A
MF C121H200N42O39
Purity 99.49%
Appearance White Powder
Certification GMP, ISO 9001, USP
Standard Enterprise standard
Usage Pharmaceutical intermediates
Min Order1 milligram
Alias: PEG-Suc-YQPPSTNKNTKSQ(d)R(d)RKGSTFEEHK-NH2;
M F: C121H200N42O39
Purity (HPLC): 98.0%
Appearance: White powder
Single Impurity(HPLC): ≤0.5%
Amino Acid Composition: ±10% of theoretical
Peptide Content(N%): ≥80.0%
Water Content(Karl Fischer): ≤8.0%
Acetate Content(HPLC): ≤10.0%
Specific Rotation: (20/D) -55.0~-65.0°(c=1 1%HAc)
MS(ESI): Consistent
Mass Balance: 95.0~105.0%
Bacterial Endotoxins: ≤5 EU/mg
Certification: GMP, ISO 9001, USP
Standard: pharma grade
Usage: Pharmaceutical intermediates.
Mechano Factor (MGF) exhibits local effects in skeletal muscle and without cannot travel through the body without modification. The problem with synthetic Mechano Factor (MGF) is that it is introduced intramuscularly and is water based so it goes into the blood stream. When used this way, Mechano Factor (MGF) only remains stable in the blood stream for a few minutes. Biologically produced MGF is made locally and does not enter the bloodstream. It is also short acting so stability is not an issue. By PEGylating the Mechano Factor (MGF) it is almost as efficient as local produced Mechano Factor (MGF) when used intramuscularly. This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule. The polyethylene glycol groups protect the peptide but do not surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein.
Base MGF which is produced in liver and secreted into the blood stream, only lasts for about 5-7 minutes before it breaks down. This is the regular "base" MGF version that's not widely used due to the short half-life. Just as IGF-1 was modified to be IGF-1LR3 (the longer acting version), the same has been done with MGF. The additive polyethylene glycol was added to the MGF chain in order to give it a half life of several days!
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